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Paliperidone (9-hydroxyrisperidone, the chief active metabolite of risperidone) is a new antipsychotic drug for the treatment of schizophrenia; a double-blind, placebo-controlled study with 6-month open-label extension showed the safety and tolerability of oral paliperidone extended release tablets in 114 old patients (mean age 70 years).

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Lurasidone (trade name: Latuda) has been approved since March 2014 for the treatment of schizophrenia in adults.

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Patients with an acute manic or mixed episode received olanzapine for 6-12 weeks.

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